Small molecules showing significant protection of mice against botulinum neurotoxin serotype A.
Botulinum neurotoxin serotype A (BoNTA) causes a life-threatening neuroparalytic disease known as botulism that could afflict large, unprotected populations if the toxin were employed in an act of bioterrorism.Current post-exposure therapy is limited to symptomatic treatment or passive immunization that is effective for treating infant botulism at